Variant Annotation Server
Upload VCF file or submit variant list and run annotation pipeline
Annotation Pipeline Tools
VEP (Variant Effect Predictor)
Annotates variants with functional consequences, SIFT, PolyPhen scores, and ClinVar clinical significance.
Annotates variants with functional consequences, SIFT, PolyPhen scores, and ClinVar clinical significance.
IMPACT Filter
Filters variants by HIGH, MODERATE, or all impact categories based on Sequence Ontology terms.
Filters variants by HIGH, MODERATE, or all impact categories based on Sequence Ontology terms.
dbNSFP & CADD
Integrates deleteriousness scores (CADD, REVEL, MetaSVM) and population frequencies (gnomAD, 1000 Genomes).
Integrates deleteriousness scores (CADD, REVEL, MetaSVM) and population frequencies (gnomAD, 1000 Genomes).
Orphanet Integration
Links variants to rare disease annotations using HPO terms from the Orphanet database.
Links variants to rare disease annotations using HPO terms from the Orphanet database.
Click or drag & drop VCF file (.vcf, .vcf.gz)
Max 50 MB — supports multi-sample VCF